I haven’t tried this yet myself, but I’m quite excited; the majority of my multimedia collection is on my home computer, but I synchronize with my work PC for convenience (and because it’s where I spend most of my time working)…

How to Sync iPhone with multiple computers

UPDATE: IT DOES WORK WITH ITUNES 8 ( THANKS DILLY! )

In order to sync your iPhone with multiple computers you always had to “erase” one iTunes library and sync with another, no longer! Thanks to Andrew Grant at Shiny Things who create a step by step instruction for syncing your iPhone with multiple computers and giving you full manual control on how you want to organize your iPhone music between multiple iTunes libraries.

This is NOT for the faint hearted as it does involve tweaking of files, please proceed with caution and BACKUP everything, especially your “iTunes Library” and “iTunes Music Library.xml” files before proceeding. I have performed this and it works flawlessly but if for any reason your iTunes or your iPhone or your data becomes destroyed, I am NOT responsible. Now that we have gotten the disclaimer aside, let’s proceed with the fun stuff.

(via tinyfish.net)